赵雁林

文章来源：　发布时间:2017-12-25

　　一、个人简介

　　赵雁林，研究员，博士研究生学历，博士研究生导师，美国哈佛大学医学院客座教授，现任中国疾病预防控制中心结控中心副主任，国家结核病参比实验室主任，中国防痨协会常务理事，中国防痨协会基础委员会主任委员，中华医学会结核病学分会基础组组长，中国医药生物技术协会实验室生物安全委员会常委，世界卫生组织实验室诊断组常委，世界卫生组织全球结核病实验室行动组（GLI）科学委员会副主席，多次出席世界卫生组织等国际会议并做大会报告，2004年北京市科技新星，2006年全国先进个人；2010年北京市新世纪百千万“百人才工程”入选计划；2010年卫生部卫生Ⅴ项目先进个人；主持并承担基因芯片国家重点支持项目863子课题、北京市自然科学基金项目、北京市科技新星项目、WHO科研合作项目、国家十一五科技重大专项、国家十二五科技重大专项、国家重大基础研究计划（973项目）以及美国NIH研究RO1等多项课题。在世界顶级医学杂志<<新英格兰医学杂志>>、《柳叶刀》等刊物中发表学术论文130余篇，主编出版学术专著10部

　　二、主要研究方向

　　结核分枝杆菌耐药机制、遗传变异规律及其分子流行病学

　　三、代表性科研项目

　　结核病流行规律研究国家十一五科技重大专项

　　我国分枝杆菌时空动态分布特征及新诊断技术应用评估国家十二五科技重大专项基于空间变异的重大感染性疾病研究国家重大基础研究计划（973项目）

　　MAS-PCR耐多药结核病评估美国NIH课题

　　四、代表性论文、成果（2011年以来）

　　1.Pang Y, Dong H, Tan Y, Deng Y, Cai X, Jing H, Xia H, Li Q, Ou X, Su B, Li X, Zhang Z, Li J, Zhang J, Huan S, Zhao Y. Rapid diagnosis of MDR and XDR tuberculosis with the MeltPro TB assay in China. Sci Rep. 2016 May 6;6:25330.

　　2.Pang Y, Zhao A, Cohen C, Kang W, Lu J, Wang G, Zhao Y, Zheng S. Current status of new tuberculosis vaccine in children. Hum Vaccin Immunother. 2016 Mar 22:1-11

　　3.Pang Y, Du J, Qin ZZ, Greenwald Z, Liu Y, Mi F, Zhao Y, Li L. An overview on tuberculosis-specific hospitals in China in 2009: results of a national survey. Eur Respir J. 2016 May;47(5):1584-7. doi: 10.1183/13993003.01854-2015. Epub 2016 Feb 25. PubMed PMID: 26917612.

　　4. Raju RM, Raju SM, Zhao Y, Rubin EJ. Leveraging Advances in Tuberculosis Diagnosis and Treatment to Address Nontuberculous Mycobacterial Disease. Emerg Infect Dis. 2016 Mar;22(3):365-9.

　　5. Fitzpatrick C, Hui Z, Lixia W, Renzhong L, Yunzhou R, Mingting C, Yanlin Z, Jin Z, Wei S, Caihong X, Cheng C, Alston T, Yan Q, Chengfei L, Yunting F, Shitong

　　H, Qiang S, Scano F, Chin DP, Floyd K. Cost-effectiveness of a comprehensive programme for drug-resistant tuberculosis in China. Bull World Health Organ. 2015 Nov 1;93(11):775-84. doi: 10.2471/BLT.14.146274. Epub 2015 Sep 14. PubMed PMID:26549905; PubMed Central PMCID: PMC4622153.

　　6.Yuen CM, Amanullah F, Dharmadhikari A, Nardell EA, Seddon JA, Vasilyeva I, Zhao Y, Keshavjee S, Becerra MC. Turning off the tap: stopping tuberculosis transmission through active case-finding and prompt effective treatment. Lancet. 2015 Dec 5;386(10010):2334-43.

　　7. Pang Y, Wang Z, Zheng H, Song Y, Wang Y, Zhao Y. Pyrazinamide resistance determined by liquid culture at low pH better correlates with genetic mutations in MDR tuberculosis isolates. J Microbiol Methods. 2015 Dec;119:142-4.

　　8. He G, Li Y, Zhao F, Wang L, Cheng S, Guo H, Klena JD, Fan H, Gao F, Gao F, Han G, Ren L, Song Y, Xiong Y, Geng M, Hou Y, He G, Li J, Guo S, Yang J, Yan D, Wang Y, Gao H, An J, Duan X, Wu C, Duan F, Hu D, Lu K, Zhao Y, Rao CY, Wang Y. The Prevalence and Incidence of Latent Tuberculosis Infection and Its Associated Factors among Village Doctors in China. PLoS One. 2015 May 21;10(5):

　　9. Pang Y, Lu J, Yang J, Wang Y, Cohen C, Ni X, Zhao Y. A novel method for diagnosis of smear-negative tuberculosis patients by combining a random unbiased Phi29 amplification with a specific real-time PCR. Tuberculosis (Edinb). 2015 Jul;95(4):411-4.

　　10. Pang Y, Zhou Y, Wang S, Song Y, Ou X, Zhao B, Zhang Z, Zhao Y. Prevalence and risk factors of mixed Mycobacterium tuberculosis complex infections in China. JInfect. 2015 Aug;71(2):231-7.

　　11. Xia H, Wang X, Li F, Longuet C, Vernet G, Goletti D, Zhao Y, Lagrange PH. Diagnostic values of the QuantiFERON-TB Gold In-tube assay carried out in China for diagnosing pulmonary tuberculosis. PLoS One. 2015 Apr 13;10(4)

　　12. Zhang Z, Pang Y, Wang Y, Cohen C, Zhao Y, Liu C. Differences in risk factors and drug susceptibility between Mycobacterium avium and Mycobacterium intracellulare lung diseases in China. Int J Antimicrob Agents. 2015 May;45(5):491-5.

　　13. Li R, Ruan Y, Sun Q, Wang X, Chen M, Zhang H, Zhao Y, Zhao J, Chen C, Xu C,Su W, Pang Y, Cheng J, Chi J, Wang Q, Fu Y, Huan S, Wang L, Wang Y, Chin DP. Effect of a comprehensive programme to provide universal access to care for sputum-smear-positive multidrug-resistant tuberculosis in China: a before-and-after study. Lancet Glob Health. 2015 Apr;3(4):e217-28.

　　14. Yang X, Yuan Y, Pang Y, Wang B, Bai Y, Wang Y, Yu B, Zhang Z, Fan M, Zhao Y. The burden of MDR/XDR tuberculosis in coastal plains population of China. PLoS One. 2015 Feb 17;10(2)

　　15. Gao L, Lu W, Bai L, Wang X, Xu J, Catanzaro A, Cárdenas V, Li X, Yang Y, Du J, Sui H, Xia Y, Li M, Feng B, Li Z, Xin H, Zhao R, Liu J, Pan S, Shen F, He J, Yang S, Si H, Wang Y, Xu Z, Tan Y, Chen T, Xu W, Peng H, Wang Z, Zhu T, Zhou F,Liu H, Zhao Y, Cheng S, Jin Q; LATENTTB-NSTM study team. Latent tuberculosis infection in rural China: baseline results of a population-based, multicentre, prospective cohort study. Lancet Infect Dis. 2015 Mar;15(3):310-9.

　　16. Sun W, Gong J, Zhou J, Zhao Y, Tan J, Ibrahim AN, Zhou Y. A spatial, social and environmental study of tuberculosis in China using statistical and GIS technology. Int J Environ Res Public Health. 2015 Jan 27;12(2):1425-48.

　　17. Zhang Z, Lu J, Liu M, Wang Y, Qu G, Li H, Wang J, Pang Y, Liu C, Zhao Y. Genotyping and molecular characteristics of multidrug-resistant Mycobacterium tuberculosis isolates from China. J Infect. 2015 Apr;70(4):335-45.

　　18. Zhang Z, Li T, Qu G, Pang Y, Zhao Y. In vitro synergistic activity of clofazimine and other antituberculous drugs against multidrug-resistant Mycobacterium tuberculosis isolates. Int J Antimicrob Agents. 2015 Jan;45(1):71-5.

　　19. Pang Y, Kang W, Zhao A, Liu G, Du W, Xu M, Wang G, Zhao Y, Zheng S. The effect of bacille Calmette-Guérin vaccination at birth on immune response in China. Vaccine. 2015 Jan 1;33(1):209-13.

　　20. Ou X, Xia H, Li Q, Pang Y, Wang S, Zhao B, Song Y, Zhou Y, Zheng Y, Zhang Z, Zhang Z, Li J, Dong H, Chi J, Zhang J, Kam KM, Huan S, Jun Y, Chin DP, Zhao Y. A feasibility study of the Xpert MTB/RIF test at the peripheral level laboratory in China. Int J Infect Dis. 2015 Feb;31:41-6.

　　21: Pang Y, Wang Y, Zhao S, Liu J, Zhao Y, Li H. Evaluation of the Xpert MTB/RIF assay in gastric lavage aspirates for diagnosis of smear-negative childhood pulmonary tuberculosis. Pediatr Infect Dis J. 2014 Oct;33(10):1047-51.

　　22. Wang Q, Lau SK, Liu F, Zhao Y, Li HM, Li BX, Hu YL, Woo PC, Liu CH. Molecular epidemiology and clinical characteristics of drug-resistant Mycobacterium tuberculosis in a tuberculosis referral hospital in China. PLoS One. 2014 Oct 10;9(10)

　　23.Li J, Liu F, Wang Q, Ge P, Woo PC, Yan J, Zhao Y, Gao GF, Liu CH, Liu C. Genomic and transcriptomic analysis of NDM-1 Klebsiella pneumoniae in spaceflight reveal mechanisms underlying environmental adaptability. Sci Rep. 2014 Aug 28;4:6216.

　　24．Ou X, Song Y, Zhao B, Li Q, Xia H, Zhou Y, Pang Y, Wang S, Zhang Z, Cheng S,Liu C, Zhao Y. A multicenter study of Cross-Priming Amplification for tuberculosis diagnosis at peripheral level in China. Tuberculosis (Edinb). 2014 Jul;94(4):428-33.

　　25． Ou X, Li Q, Xia H, Pang Y, Wang S, Zhao B, Song Y, Zhou Y, Zheng Y, Zhang Z, Li J, Dong H, Zhang J, Kam KM, Chi J, Huan S, Chin DP, Zhao Y. Diagnostic accuracy of the PURE-LAMP test for pulmonary tuberculosis at the county-level laboratory in China. PLoS One. 2014 May 1;9(5):e94544

　　26. Wang L, Zhang H, Ruan Y, Chin DP, Xia Y, Cheng S, Chen M, Zhao Y, Jiang S, Du X, He G, Li J, Wang S, Chen W, Xu C, Huang F, Liu X, Wang Y. Tuberculosis prevalence in China, 1990-2010; a longitudinal analysis of national survey data. Lancet. 2014 Jun 14;383(9934):2057-64.

　　27. Luo T, Yang C, Pang Y, Zhao Y, Mei J, Gao Q. Development of a hierarchical variable-number tandem repeat typing scheme for Mycobacterium tuberculosis in China. PLoS One. 2014 Feb 25;9(2):e89726.

　　28. Zhang Z, Pang Y, Wang Y, Liu C, Zhao Y. Beijing genotype of Mycobacterium tuberculosis is significantly associated with linezolid resistance in multidrug-resistant and extensively drug-resistant tuberculosis in China. Int J Antimicrob Agents. 2014 Mar;43(3):231-5.

　　29. Zhang Z, Lu J, Wang Y, Pang Y, Zhao Y. Prevalence and molecular characterization of fluoroquinolone-resistant Mycobacterium tuberculosis isolates in China. Antimicrob Agents Chemother. 2014;58(1):364-9.

　　30．Tan Y, Hu Z, Zhang T, Cai X, Kuang H, Liu Y, Chen J, Yang F, Zhang K, Tan S, Zhao Y. Role of pncA and rpsA gene sequencing in detection of pyrazinamide resistance in Mycobacterium tuberculosis isolates from southern China. J Clin Microbiol. 2014 Jan;52(1):291-7.

　　31．Zhang Z, Lu J, Wang Y, Pang Y, Zhao Y. Prevalence and molecular characterization of fluoroquinolone-resistant Mycobacterium tuberculosis isolates in China. Antimicrob Agents Chemother. 2014 Jan;58(1):364-9.

　　32. Zhang Z, Pang Y, Wang Y, Liu C, Zhao Y. Beijing genotype of Mycobacterium tuberculosis is significantly associated with linezolid resistance in multidrug-resistant and extensively drug-resistant tuberculosis in China. Int J Antimicrob Agents. 2013 Dec 31.

　　33. Pang Y, Lu J, Wang Y, Song Y, Wang S, Zhao Y. Study of the Rifampin Monoresistance Mechanism in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2013;57(2):893-900.

　　34. Pang Y, Song Y, Xia H, Zhou Y, Zhao B, Zhao Y. Risk factors and clinical phenotypes of Beijing genotype strains in tuberculosis patients in China.BMC Infect Dis. 2012 ;17;12:354

　　35. Zhao Y, Xu S, Wang L, et al. National survey of drug-resistant tuberculosis in China. N Engl J Med 2012;366:2161-70.

　　36．Zhang X, Zhao B, Liu L, Zhu Y, Zhao Y, Jin Q. Subpopulation analysis of heteroresistance to fluoroquinolone in Mycobacterium tuberculosis isolates from Beijing, China. J Clin Microbiol. 2012 Apr;50(4):1471-4.

　　37． Liu J, Yue J, Yan Z, Han M, Han Z, Jin L, Zhao Y. Performance assessment of the CapitalBio mycobacterium identification array system for identification of mycobacteria. J Clin Microbiol. 2012 Jan;50(1):76-80.

　　38．Tan Y, Hu Z, Zhao Y, Cai X, Luo C, Zou C, Liu X. The beginning of the rpoB gene in addition to the rifampin resistance determination region might be needed for identifying rifampin/rifabutin cross-resistance in multidrug-resistant Mycobacterium tuberculosis isolates from Southern China. J Clin Microbiol. 2012 Jan;50(1):81-5.

　　39. Pang Y, Zhou Y, Wang S, Lu J, Lu B, He G, Wang L, Zhao Y. A novel method based on high resolution melting (HRM) analysis for MIRU-VNTR genotyping of Mycobacterium tuberculosis. J Microbiol Methods. 2011 Sep;86(3):291-7.

　　40. Schürch AC, Kremer K, Warren RM, Hung NV, Zhao Y, Wan K, Boeree MJ, Siezen RJ, Smith NH, van Soolingen D. Mutations in the regulatory network underlie the recent clonal expansion of a dominant subclone of the Mycobacterium tuberculosis Beijing genotype. Infect Genet Evol. 2011 Apr;11(3):587-97.

　　41. Yu X, Jiang G, Li H, Zhao Y, Zhang H, Zhao L, Ma Y, Coulter C, Huang H. Rifampin stability in 7H9 broth and L？wenstein-Jensen medium. J Clin Microbiol. 2011 Mar;49(3):784-9.